Firing rate-dependent phase responses of Purkinje cells support transient oscillations
نویسندگان
چکیده
منابع مشابه
Firing dynamics of cerebellar purkinje cells.
Knowledge of intrinsic neuronal firing dynamics is a critical first step to establishing an accurate biophysical model of any neuron. In this study we examined cerebellar Purkinje cells to determine the bifurcations likely to underlie firing dynamics within a biophysically realistic and experimentally supported model. We show that Purkinje cell dynamics are consistent with a system undergoing a...
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Synchronous spiking during cerebellar tasks has been observed across Purkinje cells: however, little is known about the intrinsic cellular mechanisms responsible for its initiation, cessation and stability. The Phase Response Curve (PRC), a simple input-output characterization of single cells, can provide insights into individual and collective properties of neurons and networks, by quantifying...
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Recent experiments have established that information can be encoded in the spike times of neurons relative to the phase of a background oscillation in the local field potential-a phenomenon referred to as "phase-of-firing coding" (PoFC). These firing phase preferences could result from combining an oscillation in the input current with a stimulus-dependent static component that would produce th...
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Climbing fiber responses in cerebellar Purkinje cells are described as being invariant. In this issue of Neuron, Mathy et al. show that the complex spike waveform changes with the number of spikes in a climbing fiber burst, which depends on the phase of olivary oscillations. In turn, different complex spike profiles affect synaptic plasticity at parallel fiber synapses. Thus, information on inf...
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ژورنال
عنوان ژورنال: eLife
سال: 2020
ISSN: 2050-084X
DOI: 10.7554/elife.60692